The Cone-Rod Homeobox (CRX) protein is a master transcription factor that plays a non-negotiable role in the terminal differentiation, maturation, and survival of retinal photoreceptor cells (rods and cones). While CRX does not determine whether a cell becomes a photoreceptor, it dictates whether that cell successfully matures into a functioning, light-detecting neuron or fails and degenerates.
The primary mechanisms through which the CRX protein shapes retinal photoreceptor development follow a structured genetic and structural timeline: 1. Temporal Expression and Chromatin Remodeling
Cone-rod homeobox CRX controls presynaptic active zone … – PMC
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